Strand Lab Urology @ UT Southwestern

Publications

Our work produces public resources which enable and inform complex research all over the world. Here you can find a list of publications that the Strand Lab conducted, as well as studies that were enabled by our work.

Highlighted

A Cellular Anatomy of the Normal Adult Human Prostate and Prostatic Urethra
A Cellular Anatomy of the Normal Adult Human Prostate and Prostatic Urethra
Gervaise H. Henry, Alicia Malewska, Diya B. Joseph, Venkat S. Malladi, Jeon Lee, …, Malcolm P. MacConmara, Jeffrey C. Reese, Ryan C. Hutchinson, Chad M. Vezina, Douglas W. Strand
Cell Reports  ·  01 Dec 2018  ·  doi:10.1016/j.celrep.2018.11.086

All

2025

A 5-HT-mediated urethral defense against urinary tract infections
Marcela Ambrogi, Laura L. Hernandez, Douglas W. Strand, Sathish Kumar, Michael F. Romero, Jonathan Barasch, Monica Ridlon, Kimberly P. Keil Stietz, Chad M. Vezina
Proceedings of the National Academy of Sciences  ·  14 Apr 2025  ·  doi:10.1073/pnas.2409754122

2024

Enhanced prostatic Esr1+ luminal epithelial cells in the absence of SRD5A2
Christina Sharkey, Xingbo Long, Ra’ad Al‐Faouri, Douglas Strand, Aria F Olumi, Zongwei Wang
The Journal of Pathology  ·  12 Apr 2024  ·  doi:10.1002/path.6283
Transcriptomic analysis of benign prostatic hyperplasia identifies critical pathways in prostatic overgrowth and 5‐alpha reductase inhibitor resistance
Renjie Jin, Connor M. Forbes, Nicole L. Miller, John Lafin, Douglas W. Strand, …, Justin M. Cates, Qi Liu, Marisol Ramirez‐Solano, James L. Mohler, Robert J. Matusik
The Prostate  ·  03 Jan 2024  ·  doi:10.1002/pros.24661

2022

Prostate Cancer Transcriptomic Regulation by the Interplay of Germline Risk Alleles, Somatic Mutations, and 3D Genomic Architecture
Jiapei Yuan, Kathleen E. Houlahan, Susmita G. Ramanand, Sora Lee, GuemHee Baek, …, Yong Chen, Douglas W. Strand, Michael Q. Zhang, Paul C. Boutros, Ram S. Mani
Cancer Discovery  ·  15 Sep 2022  ·  doi:10.1158/2159-8290.CD-22-0027
Glucocorticoids are induced while dihydrotestosterone levels are suppressed in 5‐alpha reductase inhibitor treated human benign prostate hyperplasia patients
Renjie Jin, Connor Forbes, Nicole L. Miller, Douglas Strand, Thomas Case, …, Ned A. Porter, Krystin M. Mantione, Sarah Burke, James L. Mohler, Robert J. Matusik
The Prostate  ·  12 Jul 2022  ·  doi:10.1002/pros.24410
PSA density is associated with BPH cellular composition
Liwei Jia, Douglas W. Strand, Ramy S. Goueli, Jeffrey C. Gahan, Claus G. Roehrborn, Ryan J. Mauck
The Prostate  ·  02 Jun 2022  ·  doi:10.1002/pros.24367
5‐Alpha reductase inhibitors induce a prostate luminal to club cell transition in human benign prostatic hyperplasia
Diya B Joseph, Gervaise H Henry, Alicia Malewska, Jeffrey C Reese, Ryan J Mauck, Jeffrey C Gahan, Ryan C Hutchinson, James L Mohler, Claus G Roehrborn, Douglas W Strand
The Journal of Pathology  ·  03 Feb 2022  ·  doi:10.1002/path.5857

2021

The prostaglandin pathway is activated in patients who fail medical therapy for benign prostatic hyperplasia with lower urinary tract symptoms
RenJie Jin, Douglas W. Strand, Connor M. Forbes, Thomas Case, Justin M. M. Cates, …, Stephanie Sanchez, Zunyi Y. Wang, Dale E. Bjorling, Nicole L. Miller, Robert J. Matusik
The Prostate  ·  20 Jul 2021  ·  doi:10.1002/pros.24190
Progenitors in prostate development and disease
Diya B. Joseph, Anne E. Turco, Chad M. Vezina, Douglas W. Strand
Developmental Biology  ·  01 May 2021  ·  doi:10.1016/j.ydbio.2020.11.012

2020

Identification and characterization of cellular heterogeneity within the developing renal interstitium
Alicia R. England, Christopher P. Chaney, Amrita Das, Mohita Patel, Alicia Malewska, Daniel Armendariz, Gary C. Hon, Douglas W. Strand, Keri A. Drake, Thomas J. Carroll
Development  ·  01 Aug 2020  ·  doi:10.1242/dev.190108
Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase.
Sajjan Koirala, Jonathon Klein, Yumei Zheng, Nicole O Glenn, Travis Eisemann, …, Lawrence Lum, Chad A Brautigam, John M Pascal, Wilson K Clements, Patrick Ryan Potts
Cell reports  ·  21 Jul 2020  ·  pmid:32698014
Urethral luminal epithelia are castration-insensitive cells of the proximal prostate.
Diya B Joseph, Gervaise H Henry, Alicia Malewska, Nida S Iqbal, Hannah M Ruetten, …, Ryan C Hutchinson, Claus G Roehrborn, Linda A Baker, Chad M Vezina, Douglas W Strand
The Prostate  ·  04 Jun 2020  ·  pmid:32497356
Stromal reactivity differentially drives tumour cell evolution and prostate cancer progression
Ziv Frankenstein, David Basanta, Omar E. Franco, Yan Gao, Rodrigo A. Javier, Douglas W. Strand, MinJae Lee, Simon W. Hayward, Gustavo Ayala, Alexander R. A. Anderson
Nature Ecology & Evolution  ·  11 May 2020  ·  doi:10.1038/s41559-020-1157-y
Characterization of interstitial heterogeneity in the developing kidney
Alicia R. England, Christopher P. Chaney, Amrita Das, Mohita Patel, Alicia Malewsak, Daniel Armendariz, Gary Hon, Douglas Strand, Keri Drake, Thomas J. Carroll
Cold Spring Harbor Laboratory  ·  03 Mar 2020  ·  doi:10.1101/2020.03.02.973966
Obesity-associated inflammation induces androgenic to estrogenic switch in the prostate gland
Bichen Xue, Shulin Wu, Christina Sharkey, Shahin Tabatabaei, Chin-Lee Wu, Zhipeng Tao, Zhiyong Cheng, Douglas Strand, Aria F. Olumi, Zongwei Wang
Prostate Cancer and Prostatic Diseases  ·  06 Feb 2020  ·  doi:10.1038/s41391-020-0208-4

2019

EDITORIAL COMMENT
Douglas Strand
Urology  ·  01 Jul 2019  ·  doi:10.1016/j.urology.2019.02.035
Distinct expression patterns of SULT2B1b in human prostate epithelium
Jiang Yang, Meaghan M. Broman, Paula O. Cooper, Nadia A. Lanman, Douglas W. Strand, Colm Morrissey, Timothy L. Ratliff
The Prostate  ·  18 Jun 2019  ·  doi:10.1002/pros.23829

2018

Determining cellular heterogeneity in the human prostate with single-cell RNA sequencing
Gervaise H Henry, Douglas W Strand
Zenodo  ·  18 Dec 2018  ·  doi:10.5281/zenodo.2654018
Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories
Clarissa Gerhauser, Francesco Favero, Thomas Risch, Ronald Simon, Lars Feuerbach, …, Christoph Plass, Marie-Laure Yaspo, Jan O. Korbel, Thorsten Schlomm, Joachim Weischenfeldt
Cancer Cell  ·  01 Dec 2018  ·  doi:10.1016/j.ccell.2018.10.016
A Cellular Anatomy of the Normal Adult Human Prostate and Prostatic Urethra
Gervaise H. Henry, Alicia Malewska, Diya B. Joseph, Venkat S. Malladi, Jeon Lee, …, Malcolm P. MacConmara, Jeffrey C. Reese, Ryan C. Hutchinson, Chad M. Vezina, Douglas W. Strand
Cell Reports  ·  01 Dec 2018  ·  doi:10.1016/j.celrep.2018.11.086
Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice
Chelsea Hepler, Bo Shan, Qianbin Zhang, Gervaise H Henry, Mengle Shao, …, Alexandra L Ghaben, Angela B Mobley, Douglas Strand, Gary C Hon, Rana K Gupta
eLife  ·  28 Sep 2018  ·  doi:10.7554/eLife.39636
Prostatic collagen architecture in neutered and intact canines
Hannah Ruetten, Kyle A. Wegner, Michael F. Romero, Michael W. Wood, Paul C. Marker, Douglas Strand, Sara A. Colopy, Chad M. Vezina
The Prostate  ·  08 May 2018  ·  doi:10.1002/pros.23641
Determining the cellular heterogeneity of the normal human prostate
Douglas Strand
GUDMAP (www.gudmap.org)  ·  01 Jan 2018  ·  doi:10.25548/w-r8cm

2017

Androgenic to oestrogenic switch in the human adult prostate gland is regulated by epigenetic silencing of steroid 5α-reductase 2
Zongwei Wang, Libing Hu, Keyan Salari, Seth K Bechis, Rongbin Ge, …, Jonathan Pham, Chin-Lee Wu, Shahin Tabatabaei, Douglas W Strand, Aria F Olumi
The Journal of Pathology  ·  17 Nov 2017  ·  doi:10.1002/path.4985
Prostate cancer xenografts and hormone induced prostate carcinogenesis
Dalton T. McLean, Douglas W. Strand, William A. Ricke
Differentiation  ·  01 Sep 2017  ·  doi:10.1016/j.diff.2017.08.005
OMIP‐040: Optimized gating of human prostate cellular subpopulations
Gervaise H. Henry, Nicolas Loof, Douglas W. Strand
Cytometry Part A  ·  18 Aug 2017  ·  doi:10.1002/cyto.a.23187
Estrogen receptor coregulator binding modulators (ERXs) effectively target estrogen receptor positive human breast cancers
Ganesh V Raj, Gangadhara Reddy Sareddy, Shihong Ma, Tae-Kyung Lee, Suryavathi Viswanadhapalli, …, Vijay K Gonugunta, Douglas Strand, Rajeshwar Rao Tekmal, Jung-Mo Ahn, Ratna K Vadlamudi
eLife  ·  08 Aug 2017  ·  doi:10.7554/eLife.26857
Targeting phenotypic heterogeneity in benign prostatic hyperplasia
Douglas W. Strand, Daniel N. Costa, Franto Francis, William A. Ricke, Claus G. Roehrborn
Differentiation  ·  01 Jul 2017  ·  doi:10.1016/j.diff.2017.07.005
Molecular pathogenesis of human prostate basal cell hyperplasia
Gervaise Henry, Alicia Malewska, Ryan Mauck, Jeffrey Gahan, Ryan Hutchinson, Jose Torrealba, Franto Francis, Claus Roehrborn, Douglas Strand
The Prostate  ·  01 May 2017  ·  doi:10.1002/pros.23394

2016

Non-Cell-Autonomous Regulation of Prostate Epithelial Homeostasis by Androgen Receptor
Boyu Zhang, Oh-Joon Kwon, Gervaise Henry, Alicia Malewska, Xing Wei, …, Claus Roehrborn, Chad J. Creighton, Douglas W. Strand, Michael M. Ittmann, Li Xin
Molecular Cell  ·  01 Sep 2016  ·  doi:10.1016/j.molcel.2016.07.025
NF‐κB and androgen receptor variant 7 induce expression of SRD5A isoforms and confer 5ARI resistance
David C. Austin, Douglas W. Strand, Harold L. Love, Omar E. Franco, Magdalena M. Grabowska, …, Omar Hameed, Peter E. Clark, Robert J. Matusik, Ren J. Jin, Simon W. Hayward
The Prostate  ·  16 May 2016  ·  doi:10.1002/pros.23195
Isolation and analysis of discreet human prostate cellular populations
Douglas W. Strand, LaTayia Aaron, Gervaise Henry, Omar E. Franco, Simon W. Hayward
Differentiation  ·  01 Apr 2016  ·  doi:10.1016/j.diff.2015.10.013
Advances in prostate cancer research models: From transgenic mice to tumor xenografting models
Yuejiao Huang, Chun Cheng, Chong Zhang, Yonghui Zhang, Miaomiao Chen, Douglas W. Strand, Ming Jiang
Asian Journal of Urology  ·  01 Apr 2016  ·  doi:10.1016/j.ajur.2016.02.004

2015

NF‐κB and androgen receptor variant expression correlate with human BPH progression
David C. Austin, Douglas W. Strand, Harold L. Love, Omar E. Franco, Alex Jang, …, Peter E. Clark, Jay H. Fowke, Robert J. Matusik, Ren J. Jin, Simon W. Hayward
The Prostate  ·  28 Dec 2015  ·  doi:10.1002/pros.23140
Nfib Regulates Transcriptional Networks That Control the Development of Prostatic Hyperplasia
Magdalena M. Grabowska, Stephen M. Kelly, Amy L. Reese, Justin M. Cates, Tom C. Case, …, Peter E. Clark, Simon W. Hayward, Richard M. Gronostajski, Philip D. Anderson, Robert J. Matusik
Endocrinology  ·  17 Dec 2015  ·  doi:10.1210/en.2015-1312
The many ways to make a luminal cell and a prostate cancer cell
Douglas W Strand, Andrew S Goldstein
Endocrine-Related Cancer  ·  25 Aug 2015  ·  doi:10.1530/erc-15-0195

2014

SOX2 expression in the developing, adult, as well as, diseased prostate
X Yu, J M Cates, C Morrissey, C You, M M Grabowska, …, D W Strand, O E Franco, O Lin-Tsai, S W Hayward, R J Matusik
Prostate Cancer and Prostatic Diseases  ·  05 Aug 2014  ·  doi:10.1038/pcan.2014.29
FOXA1 deletion in luminal epithelium causes prostatic hyperplasia and alteration of differentiated phenotype
David J DeGraff, Magdalena M Grabowska, Tom C Case, Xiuping Yu, Mary K Herrick, …, Michael A Walter, Ralph Buttyan, Yajun Yi, Klaus H Kaestner, Robert J Matusik
Laboratory Investigation  ·  01 Jul 2014  ·  doi:10.1038/labinvest.2014.64
Surgical intervention for symptomatic benign prostatic hyperplasia is correlated with expression of the AP‐1 transcription factor network
Opal Lin‐Tsai, Peter E. Clark, Nicole L. Miller, Jay H. Fowke, Omar Hameed, Simon W. Hayward, Douglas W. Strand
The Prostate  ·  05 Feb 2014  ·  doi:10.1002/pros.22785

2013

Chronic Cyclic Bladder Over Distention Up-Regulates Hypoxia Dependent Pathways
Heidi A. Stephany, Douglas W. Strand, Christina B. Ching, Stacy T. Tanaka, Ginger L. Milne, …, Mark C. Adams, John W. Brock, Simon W. Hayward, Robert J. Matusik, Douglass B. Clayton
Journal of Urology  ·  01 Oct 2013  ·  doi:10.1016/j.juro.2013.02.026
SPARCL1 suppresses metastasis in prostate cancer
Yuzhu Xiang, Qingchao Qiu, Ming Jiang, Renjie Jin, Brian D. Lehmann, …, Xunbo Jin, Simon W. Hayward, Robert J. Matusik, Alfred L. George, Yajun Yi
Molecular Oncology  ·  20 Jul 2013  ·  doi:10.1016/j.molonc.2013.07.008
Deficiency in Metabolic Regulators PPARγ and PTEN Cooperates to Drive Keratinizing Squamous Metaplasia in Novel Models of Human Tissue Regeneration
Douglas W. Strand, David J. DeGraff, Ming Jiang, Mansoureh Sameni, Omar E. Franco, …, Anne Y. Wang, Justin M.M. Cates, Bonnie F. Sloane, Robert J. Matusik, Simon W. Hayward
The American Journal of Pathology  ·  01 Feb 2013  ·  doi:10.1016/j.ajpath.2012.10.007

2012

PPARγ isoforms differentially regulate metabolic networks to mediate mouse prostatic epithelial differentiation
D W Strand, M Jiang, T A Murphy, Y Yi, K C Konvinse, O E Franco, Y Wang, J D Young, S W Hayward
Cell Death & Disease  ·  09 Aug 2012  ·  doi:10.1038/cddis.2012.99

2011

PPARγ: A molecular link between systemic metabolic disease and benign prostate hyperplasia
Ming Jiang, Douglas W. Strand, Omar E. Franco, Peter E. Clark, Simon W. Hayward
Differentiation  ·  01 Nov 2011  ·  doi:10.1016/j.diff.2011.05.008
Modeling Stromal–Epithelial Interactions
Omar E. Franco, Douglas W. Strand, Simon W. Hayward
Genetically Engineered Mice for Cancer Research  ·  28 Sep 2011  ·  doi:10.1007/978-0-387-69805-2_20
Altered TGF-β Signaling in a Subpopulation of Human Stromal Cells Promotes Prostatic Carcinogenesis
Omar E. Franco, Ming Jiang, Douglas W. Strand, James Peacock, Suzanne Fernandez, Roger S. Jackson, Monica P. Revelo, Neil A. Bhowmick, Simon W. Hayward
Cancer Research  ·  14 Feb 2011  ·  doi:10.1158/0008-5472.CAN-10-3142

2010

TGF-β1 Induces an Age-Dependent Inflammation of Nerve Ganglia and Fibroplasia in the Prostate Gland Stroma of a Novel Transgenic Mouse
David A. Barron, Douglas W. Strand, Steven J. Ressler, Truong D. Dang, Simon W. Hayward, Feng Yang, Gustavo E. Ayala, Michael Ittmann, David R. Rowley
PLoS ONE  ·  29 Oct 2010  ·  doi:10.1371/journal.pone.0013751
Perspectives on Tissue Interactions in Development and Disease
D. Strand, O. Franco, D. Basanta, A. Anderson, S. Hayward
Current Molecular Medicine  ·  01 Feb 2010  ·  doi:10.2174/156652410791065363
Cancer associated fibroblasts in cancer pathogenesis
Omar E. Franco, Aubie K. Shaw, Douglas W. Strand, Simon W. Hayward
Seminars in Cell & Developmental Biology  ·  01 Feb 2010  ·  doi:10.1016/j.semcdb.2009.10.010

2009

Functional Remodeling of Benign Human Prostatic Tissues In Vivo by Spontaneously Immortalized Progenitor and Intermediate Cells
Ming Jiang, Douglas W. Strand, Suzanne Fernandez, Yue He, Yajun Yi, Andreas Birbach, Qingchao Qiu, Johannes Schmid, Dean G. Tang, Simon W. Hayward
Stem Cells  ·  17 Dec 2009  ·  doi:10.1002/stem.284
The Role of Transforming Growth Factor-β–Mediated Tumor-Stroma Interactions in Prostate Cancer Progression: An Integrative Approach
David Basanta, Douglas W. Strand, Ralf B. Lukner, Omar E. Franco, David E. Cliffel, Gustavo E. Ayala, Simon W. Hayward, Alexander R.A. Anderson
Cancer Research  ·  31 Aug 2009  ·  doi:10.1158/0008-5472.CAN-08-3957

2007

Fibroblast growth factor-2 mediates transforming growth factor-β action in prostate cancer reactive stroma
F Yang, D W Strand, D R Rowley
Oncogene  ·  16 Jul 2007  ·  doi:10.1038/sj.onc.1210663